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Faculty of Health Sciences & Medicine

Future Research Projects

EFFECT OF CALORIE RESTRICTION ON ENTERIC NEURO-DEGENERATION AND FUNCTION

Supervisor

Dr Pete Johnson Assistant Professor of Physiology

BACKGROUND

Consumption of a 40% calorie-restricted diet (CR) is known to protect against many aging related diseases including cancer and neurodegeneration. We are currently investigating the effects of CR on the neuroanatomy and function of the enteric nervous system.

AIMS OF THE PROJECT

This study will build on current research outcomes to further investigate the effects of CR on motility and water and electrolyte secretion using isolated intestinal segments from animals, and elucidate mechanisms responsible for the effects of CR. Results obtained will suggest potential therapies for the treatment of age-related gastrointestinal disorders.

METHODS

This project will combine isolated tissue bath studies with immunohistochemistry and fluoresence microscopy.